Brexpiprazole and Sertraline Combination Treatment in Posttraumatic Stress Disorder
Results of this randomized clinical trial show that brexpiprazole + sertraline combination treatment statistically significantly improved PTSD symptoms vs sertraline + placebo, indicating its potential as a new efficacious treatment for PTSD. Brexpiprazole + sertraline was tolerated by most participants, with a safety profile consistent with that of brexpiprazole in approved indications.
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Comparative Effectiveness and Safety of Pharmacological Treatments for Rapid Tranquilisation in Emergency Settings
This IPD network meta-analysis suggests that antipsychoticbenzodiazepine combinations may offer the greatest efficacy for rapid tranquilisation in emergency settings. However, the very low certainty of evidence and study heterogeneity underscore the need for individualized treatment decisions and further high-quality randomized trials.
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Optical Coherence Tomography Enables Optical Biopsy of Endometrial Tissue for Early Cancer Detection
Catheter-based 3D optical coherence tomography demonstrated high accuracy for distinguishing benign endometrium from endometrial intraepithelial neoplasia and endometrial cancer in this ex vivo study. The findings support its potential as a rapid, minimally invasive optical biopsy technique, although prospective in vivo validation is needed before clinical implementation.
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Ensitrelvir for Covid-19 Postexposure Prophylaxis in Household Contacts
Early initiation of a 5-day oral ensitrelvir regimen within 72 hours after symptom onset in an index patient significantly reduced the risk of developing Covid-19 among household contacts while maintaining a safety profile comparable to placebo. Clinical benefit was observed across major patient subgroups, including individuals at increased risk for severe disease, and treatment was associated with reduced household transmission. These findings support ensitrelvir as an effective postexposure prophylactic option for household contacts and suggest potential utility in other high-risk exposure settings where rapid outbreak control is needed.
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Artificial Intelligence-Assisted Colonoscopy Improves Polyp Detection in a Prospective Randomized Tandem Colonoscopy Study
This prospective randomized tandem study demonstrates that AI-assisted colonoscopy significantly improves overall polyp detection, with the greatest benefit observed for diminutive and Paris type 0-IIa lesions. The enhanced detection was achieved without increasing procedure withdrawal time, supporting the feasibility of real-time AI integration into routine colonoscopic practice. Although false-positive alerts occurred, they were infrequent and readily distinguishable by experienced endoscopists. Given the single-center design, relatively small sample size, and absence of adenoma detection rate analysis, larger multicenter studies are warranted to confirm the clinical impact of AI-assisted colonoscopy on colorectal cancer prevention.
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Pharmacogenomic-Informed Antidepressant Prescribing in Australian Primary Care
In this pragmatic double-blind randomized controlled trial conducted in Australian primary care, pharmacogenomic-informed antidepressant prescribing did not improve depressive symptoms compared with prescribing guided by national therapeutic guidelines. Clinical outcomes, medication tolerability, adherence, and quality of life were similar between groups, while cost-effectiveness analyses did not support routine implementation of pharmacogenomic testing in this setting. These findings suggest that broad pharmacogenomic-guided antidepressant prescribing in general practice does not provide additional clinical benefit over guideline-based management, although targeted evaluation in carefully selected patient populations may warrant further investigation.
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