FDA Issues Recommendations Regarding Mercury-Containing Dental Amalgam

FDA
Sep 28, 2020

FDA issued updated recommendations concerning dental amalgam and potential risks to certain high-risk individuals that may be associated with these mercury-containing fillings used to restore the missing structure and surfaces of a decayed tooth.

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Phase 1-2 Trial of a SARS-CoV-2 Recombinant Spike Protein Nanoparticle Vaccine

NEJM
Sep 28, 2020

Indicate that the adjuvanted, recombinant, full-length spike protein nanoparticle vaccine NVX-CoV2373 is a promising candidate that warrants testing in efficacy studies. Phase 2 has commenced on the basis of the safety results of the day 35 primary analysis, and phase 3 is in preparatory stages.

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FDA Authorizes First Point-of-Care Antibody Test for COVID-19

FDA
Sep 26, 2020

FDA issued an EUA for the first serology (antibody) point-of-care (POC) test for COVID-19. This authorization means that fingerstick blood samples can now be tested in POC settings like doctor’s offices, hospitals, urgent care centers and emergency rooms rather than having to be sent to a central lab for testing.

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Influence of Uterine Corpus Invasion on Prognosis in Stage IA2-IIB Cervical Cancer

Gynec. Oncology
Sep 25, 2020

Diagnosis of uterine corpus invasion is frequently missed. Myometrial invasion >=50% within the uterine corpus was an independent factor associated with worse prognosis in patients with cervical cancer, while myometrial invasion <50% or endometrial invasion had no effect on outcomes.

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New Kaposi's Sarcoma-Associated Herpesvirus Variant in MSM Associated With Severe Pathologies

J Infect Disease
Sep 25, 2020

Subtype C predominated among MSM living in France. The new F variant was identified in Caucasian MSM and associated with severe KSHV disease, suggesting that subtype F could be split into F1 and F2 variants.

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Cardiovascular Outcomes of T2D Patients Treated with SGLT-2 Inhibitors Versus GLP-1 Receptor Agonists In Real-Life

BMJ DRC
Sep 24, 2020

In the absence of dedicated trials, this observational study suggests that SGLT2i may be more effective than GLP-1RA in improving cardiovascular outcomes of T2D.

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Efficacy of Intra-Articular Hypertonic Dextrose (Prolotherapy) for Knee Osteoarthritis

Ann Fam Med
Sep 24, 2020

Intra-articular dextrose prolotherapy injections reduced pain, improved function and quality of life in patients with KOA compared with blinded saline injections. The procedure is straightforward and safe; the adherence and satisfaction were high.

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Preoperative Parathyroid Localization Does Not Improve Surgical Outcomes for Patients with Primary Hyperparathyroidism

Am J Surg
Sep 23, 2020

While localization may lead to minimally-invasive operations, no differences in postoperative complications or cure rates in the hands of an experienced surgeon were observed. Therefore, preoperative parathyroid localization does not improve outcomes for hyperparathyroidism and can be ordered sparingly.

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Thalamic Nuclei Volumes in Psychotic Disorders and in Youths with Psychosis Spectrum Symptoms

FDA
Sep 23, 2020

The study findings demonstrate that smaller thalamic association nuclei represent a neurodevelopmental abnormality associated with psychosis, risk for psychosis in youths, and cognitive impairment. Identifying specific thalamic nuclei abnormalities in psychosis has implications for early detection of psychosis risk and treatment of cognitive impairment in psychosis.

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