Adjunctive Psychotherapy for Bipolar Disorder

JAMA
Oct 20, 2020

This study suggests that outpatients with bipolar disorder receiving pharmacotherapy should also be offered psychosocial treatments that emphasize illness management strategies and enhance coping skills; delivering these components in family or group format may be especially advantageous.

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A Randomized Trial Comparing Antibiotics with Appendectomy for Appendicitis

NEJM
Oct 20, 2020

For the treatment of appendicitis, antibiotics were noninferior to appendectomy on the basis of results of a standard health-status measure. In the antibiotics group, nearly 3 in 10 participants had undergone appendectomy by 90 days.

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Impact of a Weekly Glucagon-Like Peptide 1 Receptor Agonist, Albiglutide, on Glycemic Control and on Reducing Prandial Insulin Use in Type 2 Diabetes Inadequately Controlled on Multiple Insulin Therap

Diabetes Care
Oct 19, 2020

A once-weekly GLP-1RA was able to substitute for prandial insulin in 54% of people, substantially reducing the number of prandial insulin injections; glycemic control improved, with the added benefits of weight loss and less hypoglycemia in the GLP-1RA arm.

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The Expected 30-Year Benefits of Early Versus Delayed Primary Prevention of Cardiovascular Disease by Lipid Lowering

Circulation
Oct 19, 2020

Substantial reduction in expected atherosclerotic cardiovascular disease risk in the next 30 years is achievable by intensive lipid lowering in individuals in their 40s and 50s with non-HDL-C >=160 mg/dL.

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Identification of Novel Risk Loci and Causal Insights for Sporadic Creutzfeldt-Jakob Disease

The Lancet
Oct 16, 2020

The first evidence of statistically robust genetic associations in sporadic human prion disease that implicate intracellular trafficking and sphingolipid metabolism as molecular causal mechanisms.

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FDA Approves First Treatment for Ebola Virus

FDA
Oct 16, 2020

FDA approved Inmazeb (atoltivimab, maftivimab, and odesivimab-ebgn), a mixture of three monoclonal antibodies, as the first FDA-approved treatment for Zaire ebolavirus (Ebola virus) infection in adult and pediatric patients.

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Understanding Transient Ischaemic Attack (TIA)

Family Practice
Oct 15, 2020

TIA is a complex medical diagnosis with multiple risk factors that may make the management complex and hence difficult for patients to undertake.

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Nebulized Tranexamic Acid for Recurring Hemoptysis in Critically Ill Patients

Int J Emerg Med
Oct 15, 2020

Tranexamic acid may be considered in the treatment of hemoptysis regardless of the underlying cause. This may be utilized pending further workup and investigation into the underlying source of the bleeding.

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AKI and Risk of CKD and Hypertension after Pediatric Cardiac Surgery

Clin J Am Soc Nephrol.
Oct 14, 2020

CKD and hypertension burden in the 4 years after pediatric cardiac surgery is high. Young age at surgery, but not AKI, is associated with their development.

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