Safety and Immunogenicity of Shorter Interval Schedules of the Novel Oral Poliovirus Vaccine Type 2 in Infants

The Lancet
Mar 04, 2024

Two nOPV2 doses administered 1 week or 2 weeks apart from age 6 weeks to 8 weeks were safe and immunogenic. Immune responses after a 2-week interval were non-inferior to those after the standard 4-week interval, but marked responses after a 1-week interval suggest that schedules with an over 1-week interval can be used to provide flexibility to campaigns to improve coverage and hasten protection during circulating vaccine-derived poliovirus type 2 outbreaks.

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Kidney Function, Albuminuria, and Risk of Incident Atrial Fibrillation

Am J Kidney Dis
Mar 01, 2024

Lower eGFR and greater albuminuria were independently associated with increased risk of incident AF. CKD should be regarded as an independent risk factor for incident AF.

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Autoimmune Disorders Associated With Surgical Remission of Cushing's Disease

Ann Intern Med.
Feb 29, 2024

The development of new-onset autoimmune disease related to remission of endogenous Cushing's disease (CD) is not well described. This study evaluated the incidence of autoimmune disease in patients after surgical remission of CD compared with patients with nonfunctioning pituitary adenomas and the clinical presentation of and risk factors for the development of new-onset autoimmune disease in CD after remission.

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Telehealth Privacy and Security Tips

Skyscape
Mar 04, 2024

Buzz, a HIPAA-complaint platform enables providers to conduct secure video conferences or calls with patients quickly, easily & seamlessly.

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Plectin Deficiency in Fibroblasts Deranges Intermediate Filament and Organelle Morphology, Migration, and Adhesion

JID
Feb 28, 2024

Plectin, a highly versatile and multifunctional cytolinker, has been implicated in several multisystemic disorders. Most sequence variations in the human plectin gene (PLEC) cause epidermolysis bullosa simplex with muscular dystrophy (EBS-MD), an autosomal recessive skin-blistering disorder associated with progressive muscle weakness.

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Family Integrated Care Shortens the Duration of Home Oxygen Therapy in Infants With Bronchopulmonary Dysplasia

Advances in Neonatal Care
Feb 27, 2024

FIC (Family Integrated Care) improved the optimal target oxygen saturation ratio before discharge and shortened the duration of HOT (Home Oxygen Therapy) in premature infants with moderate and severe BPD (bronchopulmonary dysplasia). FIC should be promoted in China's neonatal intensive care units, though it puts forward new requirements for nursing education and training.

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Safety and Efficacy of Ibrutinib in Combination With Rituximab and Lenalidomide in Previously Untreated Follicular and Marginal Zone Lymphoma

Cancer
Feb 27, 2024

IRR is highly active as frontline therapy for FL and MZL. Compared to historical results with lenalidomide and rituximab, PFS is similar with higher grade 3-4 toxicity, particularly rash.

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High Incidence of Diabetes Mellitus After Distal Pancreatectomy and Its Predictors

JCEM
Feb 26, 2024

Impaired glucose tolerance and reduced early-phase insulin response to glucose are involved in the development of new-onset diabetes after DP (Distal Pancreatectomy); the latter is an additional factor in the development of diabetes and becomes apparent when pancreatic beta cell mass is reduced after DP.

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Converging Evidence for Frontopolar Cortex as a Target for Neuromodulation in Addiction Treatment

Am J Psychiatry
Feb 22, 2024

The review highlights the importance of targeting the frontopolar area and tailoring the treatment according to interindividual variations in brain state and trait and electric field distribution patterns. This converging evidence supports the potential for treatment optimization through context, target, dose, and timing dimensions to improve clinical outcomes of transcranial brain stimulation in people with substance use disorders in future clinical trials.

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Diagnostic Challenges Between Takotsubo Cardiomyopathy and Acute Myocardial Infarction - Where Is the Emergency?

Int J Emerg Med
Feb 21, 2024

TC leads to transient LV dysfunction that mimics AMI from which it should be differentiated for a good therapeutic approach. Patients with TC should be carefully monitored during hospitalization because they have a high recovery potential if optimally treated.

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Skin-To-Skin Contact During Cesarean Birth in the United States over the Last Decade

MCN
Feb 20, 2024

There are differences in incidence and access to skin-to-skin contact during cesarean birth. Study findings emphasize the continued need to address disparities in care, increase maternal health care equity, and make skin-to-skin contact during cesarean birth available for all women who desire it.

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