Safety and Efficacy of Sodium Glucose Co-Transporter 2 Inhibitors Combined with Insulin in Adults with Type 1 Diabetes

Wiley
Sep 18, 2019

RCT shows SGLT2 inhibitors did not induce hypoglycaemia, severe hypoglycaemia, cardiovascular events, bone fracture and all-cause mortality, but increased the risk of adverse events (AE),.

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National Trends in Utilization and 1-Year Outcomes with Transplantation of HCV-Viremic Kidneys

JASN
Sep 18, 2019

By 2019, HCV-seronegative patients received the majority of kidneys transplanted from HCV-viremic donors. Widely used organ quality scores underestimated the quality of HCV-viremic kidneys based on 1-year allograft function.

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Neoadjuvant Chemotherapy With Cisplatin and Gemcitabine Followed by Chemoradiation Versus Chemoradiation for Locally Advanced Cervical Cancer

J Clin Onco
Sep 17, 2019

Study shows that the addition of NAC consisting of cisplatin and gemcitabine to standard CRT is not superior and is possibly inferior to CRT alone for the treatment of LACC.

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Dual-Energy Computed Tomography Detection of Cardiovascular Monosodium Urate Deposits in Patients with Gout

JAMA
Sep 17, 2019

Cardiovascular MSU deposits were detected by DECT significantly more often in patients with gout compared with controls and were associated with higher coronary calcium score.

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Serine and Lipid Metabolism in Macular Disease and Peripheral Neuropathy

NEJM
Sep 16, 2019

Elevated levels of atypical deoxysphingolipids, caused by variant SPTLC1 or SPTLC2 or by low serine levels, were risk factors for macular telangiectasia type 2, as well as for peripheral neuropathy

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Statement Alerting Patients and Health Care Professionals of NDMA Found in Samples of Ranitidine

FDA
Sep 16, 2019

NDMA is classified as a probable human carcinogen (a substance that could cause cancer) based on results from laboratory tests.

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Cognitive Impairment Across ALS Clinical Stages in a Population-Based Cohort

AAN
Sep 13, 2019

Findings suggest that ALS motor and cognitive components may worsen in parallel, and that cognitive impairment becomes more pronounced when bulbar function is involved.

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Lupus Low Disease Activity State as a Treatment Endpoint for Systemic Lupus Erythematosus

The Lancet
Sep 13, 2019

LLDAS attainment is associated with significant protection against flare and damage accrual in SLE. These findings validate LLDAS as an endpoint for clinical studies in SLE.

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Low-Dose Interleukin-2 Therapy in Refractory Systemic Lupus Erythematosus

The Lancet
Sep 12, 2019

Low-dose IL-2 therapy is safe and well tolerated and selectively promotes the expansion of functional regulatory T cells in patients with moderate-to-severe systemic lupus erythematosus.

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Voluntary Wheel Running has Beneficial Effects in a Rat Model of CKD-Mineral Bone Disorder (CKD-MBD)

JASN
Sep 12, 2019

Voluntary wheel running resulted in multiple beneficial systemic effects in rats with CKD and improved their physical function. Studies examining exercise interventions in patients with CKD are warranted.

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