Clinical Outcomes of Pre-Loaded Ultra-Thin DSAEK and Pre-Loaded DMEK

BMJ Open Ophthalmology
Nov 25, 2020

Pl-DMEK offers better BCVA than pl-UT-DSAEK. The higher re-bubbling rate associated with pre-loaded DMEK is of concern.

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Mechanisms Regulating Muscle Protein Synthesis in CKD

JASN
Nov 25, 2020

CKD suppresses muscle protein synthesis via epigenetic mechanisms that NO66 mediates. Blocking NO66 could suggest strategies that counter CKD-induced abnormal muscle protein catabolism.

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Suggestibility in Functional Neurological Disorder

J Neurol Neurosurg Psychiatry
Nov 24, 2020

The results corroborate the hypothesis that FND is characterised by heightened responsiveness to verbal suggestion. Atypical suggestibility may confer risk for FND and be a cognitive marker that can inform diagnosis and treatment of this condition.

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Effect of Vitamin D Supplementation, Omega-3 Fatty Acid Supplementation, or a Strength-Training Exercise Program on Clinical Outcomes in Older Adults

JAMA
Nov 24, 2020

Among adults without major comorbidities aged 70 years or older, treatment with vitamin D3, omega-3s, or a strength-training exercise program did not result in statistically significant differences in improvement in systolic or diastolic blood pressure, nonvertebral fractures, physical performance, infection rates, or cognitive function.

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FDA Approves First Treatment for Hutchinson-Gilford Progeria Syndrome

FDA
Nov 23, 2020

FDA approved Zokinvy (lonafarnib) capsules to reduce the risk of death due to Hutchinson-Gilford progeria syndrome and for the treatment of certain processing-deficient progeroid laminopathies in patients one year of age and older.

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White Rice Intake and Incident Diabetes

Diabetes Care
Nov 23, 2020

Higher consumption of white rice is associated with an increased risk of incident diabetes with the strongest association being observed in South Asia, while in other regions, a modest, nonsignificant association was seen.

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Randomized Controlled Trial of Trastuzumab w/ or w/o Chemotherapy for HER2-Positive Early Breast Cancer in Older Patients

J Clinical Oncology
Nov 20, 2020

In light of the lower toxicity and more favorable HRQoL profile, trastuzumab monotherapy can be considered an adjuvant therapy option for selected older patients.

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FDA Authorizes First COVID-19 Test for Self-Testing at Home

FDA
Nov 20, 2020

FDA issued an EUA for the first COVID-19 diagnostic test - the Lucira COVID-19 All-In-One Test Kit - a molecular (real-time loop mediated amplification reaction) single use test that is intended to detect the novel coronavirus SARS-CoV-2 that causes COVID-19.

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Amisulpride, Aripiprazole, and Olanzapine in Patients With Schizophrenia-Spectrum Disorders (BeSt InTro)

The Lancet
Nov 19, 2020

Amisulpride was more efficacious than aripiprazole or olanzapine for reducing the PANSS total scores in adults with schizophrenia-spectrum disorders. Side-effect differences among the groups were generally small.

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