Adjunctive Pimavanserin in Patients With Major Depressive Disorder

J Clin Psychiatry
Nov 19, 2019

This phase 2 study examined the efficacy and safety of pimavanserin as adjunctive therapy in patients with major depressive disorder (MDD).

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Factors Influencing Physician Risk Estimates for ACEs in Emergency Patients with Suspected ACS

BMJ
Nov 19, 2019

Emergency physicians frequently assess risk of acute cardiac events (ACEs) in patients with undifferentiated chest pain.

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Association Between Goal-Directed Planning and Self-Reported Compulsivity vs Obsessive-Compulsive Disorder Diagnosis

JAMA
Nov 18, 2019

Deficits in goal-directed planning in OCD may be more strongly associated with a compulsivity dimension than with OCD diagnosis.

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Pre-Diagnosis Exercise and Cardiovascular Events in Primary Breast Cancer

JACC CardioOnco
Nov 18, 2019

Pre-diagnosis exercise exposure is associated with a significant graded reduction in subsequent CVEs in long-term survivors of primary breast cancer.

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Obesity Is the Most Common Risk Factor for Chronic Liver Disease

Am J Gastro.
Nov 15, 2019

The aim of this study was to characterize the risk of clinically significant liver disease assessed by TE within subpopulations of a community who were stratified based on their risk factors for obesity and/or type 2 diabetes and/or hazardous alcohol use.

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Impaired Kidney Structure and Function in Spinal Muscular Atrophy

Neuro Genetics
Nov 15, 2019

This study provides new insights into systemic contributions to SMA disease pathogenesis and the need to identify coadjuvant therapies.

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Maternal Bacterial Infection During Pregnancy and Offspring Risk of Psychotic Disorders

AJP
Nov 14, 2019

The study findings suggest that maternal bacterial infection during pregnancy is associated with an elevated risk for psychotic disorders in offspring and that the association varies by infection severity and offspring sex.

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FDA Approves First Therapy to Treat Patients with Rare Blood Disorder

FDA
Nov 14, 2019

FDA granted approval to Reblozyl (luspatercept–aamt) for the treatment of anemia (lack of red blood cells) in adult patients with beta thalassemia who require regular red blood cell (RBC) transfusions.

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Statin Use in Primary Prevention of Atherosclerotic Cardiovascular Disease

JAMA
Nov 13, 2019

With similar NNT(10) to prevent 1 event, statin use in primary prevention of ASCVD according to 5 major guidelines for sensitivity, specificity, and number needed to treat

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Measuring the Severity of Respiratory Illness in the First 2 Years of Life in Preterm and Term Infants

J Pediatr.
Nov 13, 2019

Using parent-reported symptoms, COAST score was validated as a measure of respiratory illness severity in infants.

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