FDA Approves New Opioid for Intravenous Use

FDA
Aug 13, 2020

FDA approved Olinvyk (oliceridine), an opioid agonist for the management of moderate to severe acute pain in adults, where the pain is severe enough to require an intravenous opioid and for whom alternative treatments are inadequate.

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FDA Approves Targeted Treatment for Rare DMD Mutation

FDA
Aug 13, 2020

FDA granted accelerated approval to Viltepso (viltolarsen) injection for the treatment of Duchenne muscular dystrophy (DMD) in patients who have a confirmed mutation of the DMD gene that is amenable to exon 53 skipping.

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FDA Approves First Liquid Biopsy Next-Generation Sequencing Companion Diagnostic Test

FDA
Aug 12, 2020

FDA approved the first liquid biopsy companion diagnostic that also uses next-generation sequencing (NGS) technology to identify patients with specific types of mutations of the epidermal growth factor receptor (EGFR) gene in a deadly form of metastatic NSCLC.

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FDA Approves Oral Treatment for Spinal Muscular Atrophy

FDA
Aug 11, 2020

FDA pproved Evrysdi (risdiplam) to treat patients two months of age and older with spinal muscular atrophy (SMA), a rare and often fatal genetic disease affecting muscle strength and movement.

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Long-term Outcomes in Patients With Severely Reduced Left Ventricular Ejection Fraction Undergoing Percutaneous Coronary Intervention vs Coronary Artery Bypass Grafting

JAMA
Aug 10, 2020

In this study, higher rates of mortality and MACE were seen in patients who received PCI compared with those who underwent CABG. The findings may provide insight to physicians who are involved in decision-making for these patients.

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Retinal Arterial Occlusion With Multiple Retinal Emboli and Carotid Artery Occlusion Disease

BMJ Open Ophthalmology
Aug 07, 2020

RAOs with multiple emboli are rare but highly associated with severe CAOD with haemodynamic flow changes, warning critical condition in carotid/cerebral circulations.

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Minimally Invasive Surgery for Early-Stage Ovarian Cancer

Gynec. Oncology
Aug 07, 2020

Utilization of MIS for early-stage ovarian cancer has significantly increased in the United States in 2000s. MIS procedures performed at hospitals with a higher surgical volume may be associated with improved short-term perioperative outcomes.

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Pulmonary Contusions in Patients with Rib Fractures

Am J Surg
Aug 06, 2020

There is likely a correlation between contused lung volume and risk of pulmonary complications; dichotomously classifying pulmonary contusions is insufficient.

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Ticagrelor and Aspirin or Aspirin Alone in Acute Ischemic Stroke or TIA

NEJM
Aug 06, 2020

Among patients with a mild-to-moderate acute noncardioembolic ischemic stroke or TIA who were not undergoing intravenous or endovascular thrombolysis, the risk of the composite of stroke or death within 30 days was lower with ticagrelor–aspirin than with aspirin alone.

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