The Clinical Effectiveness of Sertraline in Primary Care and the Role of Depression Severity and Duration (PANDA)

The Lancet
Jan 28, 2020

Sertraline is unlikely to reduce depressive symptoms within 6 weeks in primary care.

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Prognostic Impact of the 21-Gene Recurrence Score Assay Among Young Women

J Clinical Oncology
Jan 28, 2020

The RS assay is prognostic among young women with node-negative and limited node-positive breast cancer.

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Abdominal Adipose Tissue Is Associated With Alterations in Tryptophan-Kynurenine Metabolism

J Infect Dis
Jan 27, 2020

In PWH, increase in abdominal adipose tissue was associated with increased quinolinic-to-kynurenic acid ratio, suggesting activation of proinflammatory pathway of kynurenine metabolism

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Natural Compound Library Screening Identifies New Molecules for the Treatment of Cardiac Fibrosis and Diastolic Dysfunction

Circulation
Jan 27, 2020

Identified the molecules bufalin and lycorine as drug candidates for therapeutic applications in cardiac fibrosis and diastolic dysfunction.

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The Influence of Simulated Sunlight on the Inactivation of Influenza Virus in Aerosols

J Infect Dis
Jan 24, 2020

Results are consistent with epidemiological findings that sunlight levels are inversely correlated with influenza transmission.

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Systematic Review of Doppler for Detecting Intrapartum Fetal Heart Abnormalities

Intl J Gynecol Obstet.
Jan 24, 2020

Studies and program learning are needed to translate improved detection of FHR abnormalities to improved case management in LMICs.

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Interventions and Operations 5 Years After Bariatric Surgery

JAMA
Jan 23, 2020

Helps to inform procedure-specific decision-making for prospective patients with severe obesity and their physicians.

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Endoscopic or Surgical Myotomy in Patients with Idiopathic Achalasia

NEJM
Jan 23, 2020

Trials shows gastroesophageal reflux was more common among patients who underwent POEM than among those who underwent LHM.

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The Effect of Dulaglutide on Stroke

The Lancet
Jan 22, 2020

Long-term dulaglutide use might reduce clinically relevant ischaemic stroke in people with T2D.

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Use of Professional-Mode Flash Glucose Monitoring, at 3-Month Intervals, in Adults with T2D in GP

The Lancet
Jan 22, 2020

Professional-mode flash glucose monitoring in adults with T2D in general practice did not improve the primary outcome of HbA[1c] at 12 months

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