Risk of Transfusion-Transmitted Hepatitis E Virus Infection From Pool-Tested Platelets and Plasma
HEV can be transmitted in spite of pool testing of blood donors for HEV RNA.
KEY FINDINGS: Screening of BDs with an LOD of 2,000 IU/ml reduced the risk of tt HEV infection by about 73% for red blood cell concentrates but by just 42% for platelet and fresh frozen plasma transfusions. Single donor screening (LOD <32 IU/ml) should lead to an almost 100% risk reduction.
BACKGROUND: Immunocompromised patients are at risk of chronic hepatitis E which can be acquired by blood transfusions. Currently, screening of blood donors (BDs) for HEV RNA with a limit of detection (LOD) of 2,000 IU/ml is required in Germany. However, this may result in up to 440,000 IU of HEV RNA in blood products depending on their plasma volume. We studied the residual risk of transfusion-transmitted (tt) HEV infection when an LOD of 2,000 IU/ml is applied.
DETAILS: Highly sensitive individual donor testing for HEV RNA on the Grifols Procleix Panther system (LOD 7.89 IU/ml) was performed. HEV loads were quantified by real-time PCR. Of 16,236 donors, 31 (0.19%) were HEV RNA positive. Three BDs had viral loads between 710 and 2,000 IU/ml, which pose a significant risk of tt hepatitis E with any type of blood product. Eight BDs had viral loads of >32 to 710 IU/ml, which pose a risk of tt hepatitis E with platelet or plasma transfusions because of their higher plasma volume compared to red blood cell concentrates. Eight of these 11 potentially infectious BDs were seronegative for HEV, indicating a recent infection. Only 8 of 31 donors had viral loads >2,000 IU/ml that would also have been detected by the required screening procedure and 12 had very low HEV loads (<32 IU/ml).
Our Most Popular Resources
Copyright © Elsevier Inc. All rights reserved.
Source: Cordes, A. K., Goudeva, L., Lutgehetmann, M., et al. (2022). Risk of Transfusion-Transmitted Hepatitis E Virus Infection From Pool-Tested Platelets and Plasma. J Hepatology. 2022; 76(1): 46-52. Published: January 1, 2022. DOI: 10.1016/j.jhep.2021.08.018.
